pI: 11.3574 |
Length (AA): 121 |
MW (Da): 13913 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 119 | 2vqe (L) | 5 | 124 | 57.00 | 0 | 1 | 1.61731 | 0.11 |
29 | 97 | 4kzy (X) | 48 | 124 | 39.00 | 0.00000015 | 1 | 0.959248 | -0.15 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Bradyzoite. | Sibley/Greg |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Ortholog group members (OG5_127680)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthMp085 | ribosomal protein S12 |
Arabidopsis thaliana | ArthCp001 | ribosomal protein S12 |
Arabidopsis thaliana | AT2G07675 | ribosomal protein S12 |
Arabidopsis thaliana | ArthCp047 | ribosomal protein S12 |
Babesia bovis | BBOV_IV007080 | ribosomal protein S12, putative |
Babesia bovis | BBOV_V000340 | rps12 |
Brugia malayi | Bm1_51850 | 40S ribosomal protein S23 |
Candida albicans | CaO19.2438 | likely mitochondrial ribosomal protein similar to S. cerevisiae YNR036C and to Reclinomonas americana mitochondrial ribosomal pr |
Candida albicans | CaO19.9974 | likely mitochondrial ribosomal protein similar to S. cerevisiae YNR036C and to Reclinomonas americana mitochondrial ribosomal pr |
Caenorhabditis elegans | CELE_T03D8.2 | Protein MRPS-12 |
Chlamydia trachomatis | CT_439 | 30S ribosomal protein S12 |
Dictyostelium discoideum | DidioMp22 | ribosomal protein S12 |
Drosophila melanogaster | Dmel_CG7925 | technical knockout |
Escherichia coli | b3342 | 30S ribosomal subunit protein S12 |
Echinococcus granulosus | EgrG_000498300 | mitochondrial ribosomal protein S12 |
Echinococcus multilocularis | EmuJ_000498300 | mitochondrial ribosomal protein S12 |
Homo sapiens | ENSG00000128626 | mitochondrial ribosomal protein S12 |
Loa Loa (eye worm) | LOAG_06218 | hypothetical protein |
Mycobacterium leprae | ML1880c | PROBABLE 30S RIBOSOMAL PROTEIN S12 RPSL |
Mus musculus | ENSMUSG00000045948 | mitochondrial ribosomal protein S12 |
Mycobacterium tuberculosis | Rv0682 | 30S ribosomal protein S12 RpsL |
Mycobacterium ulcerans | MUL_0763 | 30S ribosomal protein S12 |
Neospora caninum | NCLIV_060840 | ribosomal protein S12, putative |
Oryza sativa | 9268225 | Os04g0234750 |
Oryza sativa | 3131385 | ribosomal protein S12 |
Oryza sativa | 3131499 | ribosomal protein S12 |
Oryza sativa | 6450201 | ribosomal protein S12 |
Plasmodium berghei | PBANKA_0613400 | mitochondrial ribosomal protein S12 precursor, putative |
Plasmodium berghei | PBANKA_API00300 | apicoplast ribosomal protein S12 |
Plasmodium falciparum | PF3D7_API02700 | apicoplast ribosomal protein S12 |
Plasmodium falciparum | PF3D7_0412100 | mitochondrial ribosomal protein S12 precursor, putative |
Plasmodium knowlesi | PKNH_0310300 | ribosomal protein, putative |
Plasmodium knowlesi | PKNH_API03600 | apicoplast ribosomal protein S12, putative |
Plasmodium vivax | PVX_000640 | 30S ribosomal protein S12, putative |
Plasmodium yoelii | PY05324 | ribosomal protein S12, putative |
Saccharomyces cerevisiae | YNR036C | putative mitochondrial 37S ribosomal protein MRPS12 |
Schistosoma japonicum | Sjp_0104710 | ko:K02950 small subunit ribosomal protein S12, putative |
Schistosoma mansoni | Smp_095590 | 30S ribosomal protein S12 |
Schmidtea mediterranea | mk4.001771.02 | 28S ribosomal protein S12, mitochondrial |
Toxoplasma gondii | TGME49_302055 | ribosomal protein S12 |
Toxoplasma gondii | TGME49_219770 | 30S ribosomal protein S12, putative |
Treponema pallidum | TP0243 | 30S ribosomal protein S12 |
Theileria parva | TP01_0505 | 40S ribosomal protein S12, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0346 | 30S ribosomal protein S12 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu694 | Mycobacterium tuberculosis | essential | nmpdr |
b3342 | Escherichia coli | essential | goodall |
CELE_T03D8.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T03D8.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T03D8.2 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0613400 | Plasmodium berghei | Essential | plasmo |
TGME49_219770 | Toxoplasma gondii | Probably essential | sidik |
TGME49_302055 this record | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium leprae | PROBABLE 30S RIBOSOMAL PROTEIN S12 RPSL | Compounds | References |
Mycobacterium tuberculosis | 30S ribosomal protein S12 RpsL | Compounds | References |